PKA 2β polyclonal antibody BS91078
Specifications
| 50ul/100ul |
Background:
The second messenger cyclic AMP mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. One of several regulatory subunits, p-PKA IIβ reg (cAMP-dependent protein kinase type II-beta regulatory subunit), also known as PRKAR2B, is a 418 amino acid protein that is phosphorylated by the activated catalytic chain. p-PKA IIβ reg knockout mice exhibit diminished white adipose tissue and were protected against diet-induced obesity and fatty livers,as well as markedly reduced leptin mRNA. Also playing a role in the immune response, p-PKA IIβ reg suppresses CREB transcriptional activity and down-regulates IL-2 production in T-lymphocytes.
Specificity:
PKA 2β polyclonal antibody detects endogenous levels of PKA 2β protein.
Alternative names:
PRKAR2B, AI451071, AW061005, cAMP dependent protein kinase type II beta regulatory chain, cAMP dependent protein kinase type II beta regulatory subunit, cAMP-dependent protein kinase type II-beta regulatory subunit, H RG363E19.2, KAP3, MGC116401, Pkarb2, PRKAR 2, PRKAR2, PRKAR2B, Protein kinase cAMP dependent regulatory type II beta, RATDNA, RII beta, RII(beta), RIIbeta, WUGSC:H RG363E19.2,
Species reactivity:
Human, Mouse, Rat
Host:
Rabbit
Ig type:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Immunogen:
recombinant protein
Purification & Purity:
ProA affinity purified
Molecular weight:
46 kDa
Applications:
WB IP ICC/IF IHC FC
Usage:
WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Precautions:
For research use only, not for use in diagnostic procedure.
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com