Background:

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110 expression is restricted to white blood cells. It has been shown to bind p85α and β, but it apparently does not phosphorylate these subunits. p110δ seems to have the capacity to autophosphorylate. p110γ does not interact with the p85 subunits. It has been shown to be activated by α and β γ heterotrimeric G proteins.

Specificity:

PI3K p110β polyclonal antibody detects endogenous levels of PI3K p110β protein.

Alternative names:

PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, PtdIns-3-kinase subunit beta, PtdIns-3-kinase subunit p110-beta, p110beta, PIK3CB, 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, 5-bisphosphate 3-kinase catalytic subunit beta isoform, DKFZp779K1237, MGC133043, OTTHUMP00000216901, OTTHUMP00000216904, p110 BETA, p110Beta, Phosphatidylinositol 3 kinase catalytic beta polypeptide, Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform, Phosphatidylinositol-4, Phosphoinositide 3 kinase catalytic beta polypeptide, PI3 kinase p110 subunit beta, PI3-kinase subunit beta, PI3K, PI3K beta, PI3K-beta, PI3Kbeta, PI3KCB, PIK3C1, Pik3cb, PK3CB, PtdIns 3 kinase p110, PtdIns-3-kinase subunit beta, PtdIns-3-kinase subunit p110-beta,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

123 kDa

Applications:

WB IP FC

Usage:

WB:1:1,000 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com