Background:

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Specificity:

PDX1 polyclonal antibody detects endogenous levels of PDX1 protein.

Alternative names:

PDX-1, GSF, IPF-1, IUF-1, IDX-1, STF-1, Glucose sensitive factor, Glucose-sensitive factor, GSF, IDX 1, IDX-1, IDX1, Insulin promoter factor 1, Insulin promoter factor 1 homeodomain transcription factor, Insulin upstream factor 1, IPF 1, IPF-1, IPF1, Islet/duodenum homeobox 1, Islet/duodenum homeobox-1, IUF 1, IUF-1, IUF1, MODY4, Pancreas/duodenum homeobox 1, Pancreas/duodenum homeobox protein 1, pancreatic and duodenal homeobox P, PDX 1, PDX-1, PDX1, PDX1, Somatostatin transactivating factor 1, Somatostatin-transactivating factor 1, STF 1, STF-1, STF1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

Applications:

WB IHC ICC/IF

Usage:

IHC:1:50-1:200 ICC/IF:1:50-1:200 WB:1:500

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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