Background:

Oxidoreductase-protein disulfide isomerase (PDI) is a homodimer consisting of subunits that catalyzes thiol-disulfide exchange, mediates folding of newly synthesized proteins and functions as a molecular chaperone. PDI localizes to the lumen of the endoplasmic reticulum (ER), where in conjunction with folding-helper proteins, such as immunoglobulin heavy chain binding protein (BiP), mediates tertiary and quaternary protein-processing. Cell surface PDI induces sulfhydryl-mediated conformational changes in integrin-mediated adhesion receptor-ligand interactions, thereby regulating integrin responses and cell adhesion. Additionally, PDI functions as a subunit of two more complex enzyme systems: the prolyl-4-hydroxylase and the triacylglycerol transfer proteins.

Specificity:

PDI polyclonal antibody detects endogenous levels of PDI protein.

Alternative names:

PDIp, Pdia2, Pancreas specific protein disulfide isomerase, Pancreas-specific protein disulfide isomerase, Pancreatic protein disulfide isomerase, PDA2, PDI, PDIA2, PDIA2, PDIp, PDIR, Protein disulfide isomerase A2, Protein disulfide isomerase, Protein disulfide isomerase associated 2, Protein disulfide isomerase family A member 2, Protein disulfide isomerase pancreatic, Protein disulfide-isomerase A2, Rho GDP dissociation inhibitor gamma,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

58 kDa

Applications:

WB FC

Usage:

WB:1:1,000-1:2,000 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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