Background:

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Specificity:

p53DINP1 polyclonal antibody detects endogenous levels of p53DINP1 protein.

Alternative names:

p53DINP1, TP53INP1, P53DINP1, SIP, DKFZp434M1317, FLJ22139, p53 damage inducible nuclear protein 1, p53 dependent damage inducible nuclear protein 1, p53 inducible nuclear protein 1, p53 inducible p53DINP1, p53-dependent damage-inducible nuclear protein 1, p53DINP1, SIP, Stress induced protein, Stress-induced protein, T53I1, Teap, TP53 DINP1, TP53 INP1, TP53DINP1, TP53INP1, TP53INP1A, TP53INP1B, Tumor protein p53 inducible nuclear protein 1, Tumor protein p53-inducible nuclear protein 1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Full length recombinant protein of human p53DINP1.

Purification & Purity:

ProA affinity purified

Molecular weight:

27 kDa

Applications:

WB ICC IF IHC

Usage:

WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com