Background:

P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. One of several proteins in the HSP 90-based molecular chaperone complex, P23 promotes the breakdown of transcriptional regulatory complexes by disrupting receptor-mediated transcriptional activation. P23 acts in a hormone-dependent manner to chaperone estrogen receptor alpha (ERα), a steroid complex, to its mature form and to regulate the expression of ERα-related genes. Localized to the cytoplasm, P23 interacts with the glucocorticoid receptor (GR) and, through disassembly of the GR transcription machinery, is thought to inhibit GR-dependent transcription. The involvement of P23 in various steroid receptor-mediated pathways suggests close involvement in signal transduction and regulation of cellular processes. Upregulation of P23 is implicated in the invasion and metastasis of various cancers.

Specificity:

p23 polyclonal antibody detects endogenous levels of p23 protein.

Alternative names:

cPGES, PTGES3, P23, TEBP, Co chaperone p23, cPGES, Cytosolic prostaglandin E synthase, Cytosolic prostaglandin E2 synthase, Hsp90 co chaperone, Hsp90 co-chaperone, P23, Progesterone receptor complex, Progesterone receptor complex p23, Prostaglandin E synthase 3 (cytosolic), Prostaglandin E synthase 3, PTGES 3, PTGES3, Sid 3177, TEBP, TEBP, Telomerase binding protein p23, Telomerase-binding protein p23, Unactive progesterone receptor 23 kD,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

23 kDa

Applications:

WB ICC IHC IP

Usage:

WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:100-1:500 IP:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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