Background:

AGP (α1-acid glycoprotein) is an acute phase plasma protein synthesized by the liver. It functions to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, it also mediates the extravasation of cells during infection and inflammation. Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides. AGP has a high affinity, low capacity binding for basic drugs at physiological pH. In human plasma, AGP is found at levels of 0.5-1.4 mg/ml, though this is elevated during acute inflammation, and, as a result, levels of this protein can be used to diagnose inflammatory conditions. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively. Abnormal expression of the APG-1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the APG-2 gene are associated with different types of carcinomas.

Specificity:

ORM1 polyclonal antibody detects endogenous levels of ORM1 protein.

Alternative names:

AGP 1, OMD 1, ORM1, AGP1, A1AG1, AGP 1, AGP A, AGP, AGP1, Alpha 1 acid glycoprotein, Alpha-1-acid glycoprotein 1, alpha-1-AGP, Epididymis secretory sperm binding protein Li 153w, glycoprotein, alpha-1-acid, of serum, HEL S 153w, OMD 1, ORM, ORM1, Orosomucoid 1, Orosomucoid-1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

Protein affinity purified

Molecular weight:

35 kDa

Applications:

WB IHC FC

Usage:

WB:1:500-1:2000 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com