Background:

The oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors include OLIG1-OLIG3, which differ in tissue expression. OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas. Therefore, OLIG proteins are candidates for molecular markers of human glial brain tumors, which are the most common primary malignancies of the human brain.

Specificity:

Olig2 polyclonal antibody detects endogenous levels of Olig2 protein.

Alternative names:

Oligo2, bHLHb1, bHLHe19, OLIG2, Basic domain helix loop helix protein class B 1, Basic helix loop helix protein class B 1, BHLHB, bHLHB1, bHLHe19, Class B basic helix loop helix protein 1, Class B basic helix-loop-helix protein 1, class E basic helix loop helix protein 19, Class E basic helix-loop-helix protein 19, Human protein kinase C binding protein RACK17, Olig2, OLIG2, Oligo2, Oligodendrocyte lineage transcription factor 2, Oligodendrocyte specific bHLH transcription factor 2, Oligodendrocyte transcription factor 2, OTTHUMP00000067569, OTTHUMP00000067570, PRKCBP2, Protein kinase C binding protein 2, Protein kinase C binding protein RACK17, Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17, RACK17,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

32 kDa

Applications:

WB IHC

Usage:

WB:1:500-1:1,000 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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