Background:

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.  The OGG1 gene encodes 8 isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria.

Specificity:

OGG1 polyclonal antibody detects endogenous levels of OGG1 protein.

Alternative names:

AP lyase, OGG1, MMH, MUTM, OGH1, 8 hydroxyguanine DNA glycosylase, 8 oxoguanine DNA glycosylase 1, 8 oxoguanine DNA glycosylase, AP lyase, DNA (apurinic or apyrimidinic site) lyase, DNA apurinic or apyrimidinic site lyase, DNA lyase, DNA-(apurinic or apyrimidinic site) lyase, HMMH, HOGG 1, HOGG1, MMH, MUTM, N glycosylase, Ogg 1, Ogg1, OGG1, OGH 1, OGH1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

39 kDa

Applications:

WB IHC

Usage:

WB:1:500 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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