Background:

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.

Specificity:

Nucleostemin polyclonal antibody detects endogenous levels of Nucleostemin protein.

Alternative names:

NNP47, GNL3, E2IG3, NS, C77032, E2 induced gene 3 protein, E2-induced gene 3 protein, E2IG3, Estradiol induced nucleotide binding protein, GNL3, GNL3, Guanine nucleotide binding protein like 3 (nucleolar), Guanine nucleotide binding protein like 3, Guanine nucleotide-binding protein-like 3, MGC800, NNP47, Novel nucleolar protein 47, NS, Nucleolar GTP binding protein 3, Nucleolar GTP-binding protein 3, Nucleostemin, Putative nucleotide binding protein estradiol induced,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein corresponding to the C-terminus of human Nucleostemin.

Purification & Purity:

ProA affinity purified

Molecular weight:

62 kDa

Applications:

WB ICC IHC FC

Usage:

WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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