Background:

The heredity disease chronic granulomatous disease (CGF) has been linked to mutations in p47phox and p67phox. The cytosolic proteins p47phox and p67phox, also designated neutrophil cytosol factor 1(NCF1) and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47phox and p67phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47phox and p67phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67phox has been shown to interact with the proline rich domain of p47phox, suggesting that p47phox may faciliate the transport of p67phox to the membrane.

Specificity:

NOXA2 polyclonal antibody detects endogenous levels of NOXA2 protein.

Alternative names:

NCF-2, NCF2, NOXA2, P67PHOX, 67 kDa neutrophil oxidase factor, Chronic granulomatous disease autosomal 2, FLJ93058, NADPH oxidase activator 2, NCF-2, Ncf2, NCF2, Neutrophil cytosol factor 2, Neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2), Neutrophil NADPH oxidase factor 2, NOXA2, P67 PHOX, p67-phox, p67phox,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within Human NOXA2 aa 150-300.

Purification & Purity:

ProA affinity purified

Molecular weight:

60/47 kDa

Applications:

WB IHC IP

Usage:

WB:1:500 IHC:1:50-1:200 IP:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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