Background:

The NFAT (nuclear factor of activated T cells) family of transcription factors regulates cytokine expression in T cells. Members of the family include NFATc1 (NFATc), NFATc2 (NFATp), NFATn, NFATc3 (NFAT4, NFATx) and NFATc4 (NFAT3). Recognition of antigen by the T cell receptor (TCR) eventually activates the calcium-dependent protein phosphatase calcineurin. Once activated, calcineurin stimulates the translocation of NFATc1 (cytoplasmic) from the cytoplasm to the nucleus where it associates with NFATn (nuclear). Like NFATc1, NFATc2 resides in the cytoplasm and translocates to the nucleus subsequent to activation of calcineurin. Once in the nucleus, NFATc2 synergizes with AP-1 transcription factors to initiate transcription of cytokine genes. NFATc3 and NFATc4 share 65% sequence identity with other members of the NFAT family. They are similar to NFATc2 in that they also synergize with the AP-1 family of proteins.

Specificity:

NFAT1 polyclonal antibody detects endogenous levels of NFAT1 protein.

Alternative names:

NF-ATc2, NFATc2, NF-ATp, NFATC2, AI607462, cytoplasmic 2, KIAA0611, NF ATc2, NF ATp, NF-ATc2, NF-ATp, NFAC2, NFAT 1, NFAT pre existing subunit, NFAT pre-existing subunit, NFAT transcription complex, preexisting component, NFAT1, NFAT1-D, NFATc2, NFATp, Nuclear factor of activated T cells cytoplasmic 2, Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2, Nuclear factor of activated T cells pre-existing component, Nuclear factor of activated T cells, preexisting component, Nuclear factor of activated T-cells, Preexisting nuclear factor of activated T cells 2, T cell transcription factor NFAT 1, T-cell transcription factor NFAT1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

135 kDa

Applications:

WB ICC/IF IHC FC

Usage:

WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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