Background:

The basic helix-loop-helix (bHLH) proteins are transcription factors that are required for several aspects of development, including cell type determination, terminal differentiation and sex determination. The HLH domain is required for dimerization, while the basic region makes specific contacts with DNA. Members of the myogenic determination family, MyoD, myf5, myogenin and MRF4, all have bHLH domains. These proteins heterodimerize with members of the E protein family and initiate myogenesis. Neuro D has been identified as a bHLH transcription factor functioning in neurogenic differentiation. Neuro D is expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation into mature neurons. Moreover, ectopic expression of Neuro D in Xenopus embryos induces premature differentiation of neuronal precursors and Neuro D can convert presumptive epidermal cells into neurons.

Specificity:

NeuroD1 polyclonal antibody detects endogenous levels of NeuroD1 protein.

Alternative names:

NeuroD, NeuroD1, bHLHa3, NEUROD1, atonal, basic helix loop helix transcription factor, BETA 2, Beta cell E box transactivator 2, BETA2, BHF 1, BHF1, bHLHa3, class A basic helix loop helix protein 3, Class A basic helix-loop-helix protein 3, MODY 6, MODY6, NDF1, NeuroD, NeuroD1, Neurogenic differentiation 1, Neurogenic differentiation factor 1, neurogenic helix loop helix protein NEUROD, Neuronal differentiation 1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

45 kDa

Applications:

WB IP

Usage:

WB:1:500-1:1,000 IP:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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