Background:

Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.

Specificity:

Nesprin 1 polyclonal antibody detects endogenous levels of Nesprin 1 protein.

Alternative names:

KASH1, Myne-1, Syne-1, SYNE1, C6orf98, KIAA0796, KIAA1262, KIAA1756, MYNE1, 8B, ARCA1, C6orf98, CPG2, CPG2 full length, dJ45H2.2, EDMD4, Enaptin, Myne-1, MYNE1, Myocyte nuclear envelope protein 1, Nesp1, Nesprin-1, Nuclear envelope spectrin repeat protein 1, SCAR8, Spectrin repeat containing nuclear envelope 1, Synaptic nuclear envelope protein 1, Synaptic nuclei expressed gene 1, Syne-1, SYNE1, SYNE1, SYNE1B,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

112 kDa

Applications:

WB ICC IF IHC FC

Usage:

WB:1:500-1:2,000 ICC:1:200-1:1,000 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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