Background:

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (NDUFS4) also known as NADH-ubiquinone oxidoreductase 18 kDa subunit is an enzyme that in humans is encoded by the NDUFS4 gene. This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase), plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome (ND1-6, ND4L) and the remainder by nuclear genes. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome.

Specificity:

Ndufs4 polyclonal antibody detects endogenous levels of Ndufs4 protein.

Alternative names:

CI-18 kDa, CI-AQDQ, NDUFS4, AQDQ, CI 18, CI 18 kDa, CI AQDQ, CI-18 kDa, CI-AQDQ, Complex I 18 kDa, Complex I AQDQ, Complex I-18 kDa, Complex I-AQDQ, mitochondrial, mitochondrial respiratory chain complex I (18 KD subunit), NADH coenzyme Q reductase, NADH dehydrogenase (ubiquinone) Fe S protein 4 18kDa, NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, NADH dehydrogenase, NADH ubiquinone oxidoreductase 18 kDa subunit, NADH-ubiquinone oxidoreductase 18 kDa subunit, NDUFS4, NDUS4_HUMAN antibody

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Full length recombinant protein.

Purification & Purity:

Protein A purified.

Molecular weight:

20 kDa

Applications:

WB IP IHC FC

Usage:

WB:1:500-1:1,000 IP:1:10-1:50 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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