Background:

The N-myc downstream regulated gene (NDRG) family is comprised of four members, namely NDRG1, NDRG2, NDRG3 and NDRG4, all of which share 57-65% homology. NDRG2 (NDRG family member 2), also known as SYLD, is a 371 amino acid protein that localizes to both the cytoplasm and the perinuclear region in neurons. Expressed at high levels in heart, brain, dendritic cells, salivary gland and skeletal muscle and at lower levels in liver and kidney, NDRG2 is thought to be involved in dendritic and neuronal cell differentiation and outgrowth. Additionally, NDRG2 expression is downregulated in a variety of carcinomas, including liver cancer, pancreatic cancer and meningioma, suggesting a possible role for NDRG2 in tumor suppression. NDRG2 is found in brain lesions of Alzheimer Disease (AD)-affected patients and is thought to be associated with the progression of AD. Five isoforms of NDRG2 exist due to alternative splicing events.

Specificity:

NDRG2 polyclonal antibody detects endogenous levels of NDRG2 protein.

Alternative names:

NDRG2, KIAA1248, SYLD, Antidepressant related protein ADRG123, Cytoplasmic protein Ndr1, DKFZp781G1938, FLJ25522, KIAA1248, N myc downstream regulated gene 2, N myc downstream regulator 2, NDR1 related protein NDR2, NDRG 2, NDRG family member 2, NDRG1 related protein, NDRG2, NDRG2, Protein NDRG2, Protein Syld709613, SYLD, Syld709613 protein,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human NDRG2 1-150 aa.

Purification & Purity:

Protein affinity purified.

Molecular weight:

41 kDa

Applications:

WB ICC IHC FC

Usage:

WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:100 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com