Background:

Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.

Specificity:

MMP-17 polyclonal antibody detects endogenous levels of MMP-17 protein.

Alternative names:

MMP-17, MT-MMP 4, MTMMP4, MT4-MMP, MT4MMP, MMP17, MT4MMP, Matrix metalloproteinase 17, Matrix metalloproteinase 17 membrane inserted, Matrix metalloproteinase-17, Membrane type 4 matrix metalloproteinase, Membrane type matrix metalloproteinase 4, Membrane-type matrix metalloproteinase 4, Membrane-type-4 matrix metalloproteinase, MMP 17, MMP-17, Mmp17, MMP17, MT MMP 4, MT MMP4, MT-MMP 4, MT4 MMP, MT4-MMP, MT4MMP, MTMMP 4, MTMMP4,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human MMP17 aa 1-250.

Purification & Purity:

ProA affinity purified

Molecular weight:

67 kDa

Applications:

ICC IF IHC WB

Usage:

ICC:1:50 IHC:1:50 WB:1:500

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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