Background:

Mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) are homologs for the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins and are mediators of mitochondrial fusion. A GTPase domain is required for Mfn protein function but the molecular mechanisms of the GTPase-dependent reaction as well as the functional division of the two Mfn proteins are unknown. They are essential for embryonic development and may play a role in the pathobiology of obesity. Although the Mfn1 and Mfn2 genes are broadly expressed, they show different levels of expression in different tissues. Two Mfn1 transcripts are elevated in heart, while Mfn2 mRNA is abundantly expressed in heart and muscle tissue but present only at low levels in many other tissues. Mfn1 localizes to mitochondria and participates in at least two different high molecular weight protein complexes in a GTP-dependent manner. Purified recombinant Mfn1 exhibited approximately eightfold higher GTPase activity than Mfn2.

Specificity:

Mitofusin 1 polyclonal antibody detects endogenous levels of Mitofusin 1 protein.

Alternative names:

MFN1, Fzo homolog, Hfzo1, Hfzo2, MFN 1, Mfn1, MFN1, Mitochondrial transmembrane GTPase Fzo 1, Mitochondrial transmembrane GTPase FZO 2, Mitochondrial transmembrane GTPase FZO1B, Mitofusin 1, Mitofusin-1, Mitofusin1, MS996, Putative transmembrane GTPase, Transmembrane GTPase MFN1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

84 kDa

Applications:

WB IP FC

Usage:

WB:1:1,000-1:2,000 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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