Background:

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Specificity:

MINA53 polyclonal antibody detects endogenous levels of MINA53 protein.

Alternative names:

ROX, MINA, 60S ribosomal protein L27a histidine hydroxylase, Bifunctional lysine specific demethylase and histidyl hydroxylase MINA, FLJ14393, Histone lysine demethylase MINA, MDIG, MINA, MINA, Mineral dust-induced gene protein, Myc induced nuclear antigen 53 kDa, MYC induced nuclear antigen, MYC-induced nuclear antigen, NO52, Nucleolar protein 52, Ribosomal oxygenase MINA, ROX,

Species reactivity:

Human, Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

53 kDa

Applications:

WB ICC/IF

Usage:

WB:1:500-1:2,000 ICC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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