Background:

A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

Specificity:

MEK3/6 polyclonal antibody detects endogenous levels of MEK3/6 protein.

Alternative names:

MAP kinase kinase 3, MAPKK 3, MEK 3, SAPK kinase 2, SAPKK-2, SAPKK2, MAP2K3, MAP kinase kinase 6, MAPKK 6, MEK 6, SAPK kinase 3, SAPKK-3, SAPKK3, MAP2K6, Dual specificity mitogen activated protein kinase kinase 6, Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAP kinase kinase 6, map2k3, MAP2K6, MAPK/ERK kinase 3, MAPK/ERK kinase 6, MAPKK 3, MAPKK 6, MAPKK3, MAPKK6, MEK 3, MEK 6, Mitogen activated protein kinase kinase 3, Mitogen activated protein kinase kinase 6, MKK3, MKK6, MP2K3, PRKMK3, PRKMK6, Protein kinase, mitogen activated, kinase 6 (MAP kinase kinase 6), SAPK kinase 2, SAPKK 3, SAPKK-2, SAPKK2, SAPKK3, Stress activated protein kinase kinase 3, Stress-activated protein kinase kinase 2,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

39/37 kDa

Applications:

WB ICC/IF IHC IP FC

Usage:

WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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