Background:

NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis. NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals. Conserved oocyte-specific expression of NLRP5 is consistent among many mammalian species. As a member of the subcortical maternal complex (SCMC), it plays an essential role for zygotes to progress beyond the first embryonic cell divisions. NLRP5 also localizes to the nuclear envelope and mitochondria in germinal vesicle oocytes, suggesting a possible role in mitochondrial function.

Specificity:

MATER polyclonal antibody detects endogenous levels of MATER protein.

Alternative names:

MATER, NALP5, CLR19.8, MATER, Mater protein homolog, Maternal antigen that embryos require, NACHT, leucine rich repeat and PYD containing 5, NACHT, LRR and PYD domains-containing protein 5, NALP5, NLR family, pyrin domain containing 5, NLRP5, Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5, PAN11, PYPAF8,

Species reactivity:

Human, mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

peptide

Purification & Purity:

Peptide affinity purified

Molecular weight:

134 kDa

Applications:

ICC

Usage:

ICC:1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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