Background:

MARK3 (MAP/microtubule affinity-regulating kinase 3), also known as C-TAK1 (Cdc25C-associated protein kinase 1), EMK-2 (ELKL motif kinase 2), protein kinase STK10 or serine/threonine-protein kinase p78, is a 753 amino acid peripheral membrane protein that phosphorylates Cdc25C on Serine 216 and is ubiquitously expressed in various human tissue and cell lines. Existing as six alternatively spliced isoforms, MARK3 belongs to the Ser/Thr protein kinase family and the protein kinase superfamily. MARK3 has been suggested to mediate the binding of the 14-3-3 proteins through its kinase activity and acts as a negative regulator of mitosis. The gene encoding MARK3 maps to human chromosome 14q32.3 and mouse chromosome 12 F1.

Specificity:

MARK3 polyclonal antibody detects endogenous levels of MARK3 protein.

Alternative names:

cTAK1, EMK-2, Par-1a, MARK3, CTAK1, EMK2, C-TAK1, Cdc25C associated protein kinase 1, Cdc25C-associated protein kinase 1, cTAK1, ELKL motif kinase 2, EMK-2, Emk2, ETK 1, KIAA4230, KP78, MAP microtubule affinity regulating kinase 3, MAP/microtubule affinity-regulating kinase 3, Mark3, MARK3, Par 1a, PAR1A, Protein kinase STK10, Ser/Thr protein kinase PAR-1, Serine threonine protein kinase p78, Serine/threonine-protein kinase p78, SerThr protein kinase PAR 1 antibody

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human Mark3 aa 600-750.

Purification & Purity:

Protein A purified.

Molecular weight:

84 kDa

Applications:

WB IP ICC/IF IHC FC

Usage:

WB:1:500 IP:1:10-1:50 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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