Background:

The lactate dehydrogenase family (LDH) catalyzes the final step of anaerobic glycolysis, the conversion of L-lactate and NAD to pyruvate and NADH. The LDH family consists of three members, LDH-A, LDH-B and LDH-C, all of which form tetramers consisting four subunits. However, each family member displays a specific tissue distribution pattern with LDH-A and LDH-B predominant in several tissues, specifically LDH-A in muscle and LDH-B in heart, while LDH-C expression is confined to the testis and sperm. LDHs function as powerful markers for germ cell tumors. The genes encoding human LDH-A and LDH-C map to chromosome 11, while the human LDH-B gene maps to chromosome 12. Deficiency in the LDH-A gene is linked to exertional myoglobinuria.

Specificity:

LDHA/LDHB polyclonal antibody detects endogenous levels of LDHA/LDHB protein.

Alternative names:

LDH-A, LDH-M, LDHA, PIG19, LDH-B, LDH-H, LDHB, Cell proliferation-inducing gene 19 protein, GSD11, L lactate dehydrogenase B chain, L-lactate dehydrogenase A chain, Lactate dehydrogenase A, Lactate dehydrogenase B, Lactate dehydrogenase H chain, Lactate dehydrogenase M, LDH A, LDH B, LDH H, LDH heart subunit, LDH M, LDH muscle subunit, LDH-A, LDH-M, LDH1, ldha, LDHA, LDHBD, LDHM, MS1111, PIG19, Proliferation inducing gene 19, Renal carcinoma antigen NY REN 46, Renal carcinoma antigen NY-REN-59, TRG 5, TRG5,

Species reactivity:

Human, Mouse, Rat, zebrafish

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

37 kDa

Applications:

WB ICC/IF IHC IP FC

Usage:

WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:200-1:500 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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