Background:

Laminins are heterotrimeric, noncollagenous glycoproteins composed of alpha, beta, and gamma chains. Through interactions with integrins, dystroglycan and other receptors, laminins contribute to cell differentiation, cell shape and migration, and maintenance of tissue phenotypes and survival. Laminin alpha 3/Laminin-5, also known as epiligrin, includes alpha 3, beta 3, and gamma 2 subunits. It is abundant in transitional epithelium, stratified squamous epithelia, lung mucosa and other epithelial glands and contributes to initiation and maintenance of epithelial cell anchorage to the underlying connective tissue. Within aa 21?1713 of the alpha 3 subunit, human and mouse share 77% amino acid sequence identity.

Specificity:

Laminnin α3 polyclonal antibody detects endogenous levels of Laminnin α3 protein.

Alternative names:

E170, LAMA3, E170, Epiligrin 170 kDa subunit, Epiligrin subunit alpha, Kalinin subunit alpha, LAMA3, LAMA3A, Laminin 5 alpha3, Laminin A3, laminin alpha 3, laminin alpha3, Laminin subunit alpha-3, Laminin-5 subunit alpha, Laminin-6 subunit alpha, Laminin-7 subunit alpha, laminin5 alpha 3, Laminin5 alpha3, LAMNA, LOCS, Nicein subunit alpha,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

367 kDa

Applications:

WB ICC/IF

Usage:

WB:1:1,000-1:2,000 ICC:1:100-1:500

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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