Background:

Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.

Specificity:

KHSRP polyclonal antibody detects endogenous levels of KHSRP protein.

Alternative names:

FUSE-binding protein 2, KSRP, KHSRP, FUBP2, Far upstream element-binding protein 2, FBP2, FUBP2, FUBP2, FUSE binding protein 2, FUSE-binding protein 2, KH type splicing regulatory protein (FUSE binding protein 2), KH type splicing regulatory protein, KH type-splicing regulatory protein, KHSRP, KSRP, p75,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Purification & Purity:

ProA affinity purified

Molecular weight:

73 kDa

Applications:

WB ICC IF IHC IP

Usage:

WB:1:500-1:2,000 ICC/IF:1:50-1:200 IHC:1:50-1:200 IP:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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