Background:

c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced).

Specificity:

JNK3 polyclonal antibody detects endogenous levels of JNK3 protein.

Alternative names:

MAP kinase 10, MAPK 10, SAPK1b, MAPK10, c Jun kinase 3, c-Jun N-terminal kinase 3, cJun N terminal kinase 3, FLJ12099, FLJ33785, JNK3 alpha protein kinase, JNK3, JNK3A, MAP kinase 10, MAP kinase, MAP kinase p49 3F12, MAPK 10, Mapk10, MGC50974, mitogen activated protein kinase 10, Mitogen-activated protein kinase 10, MK10, p493F12, p54bSAPK, PRKM10, protein kinase mitogen activated 10, SAPK1b, Stress activated protein kinase 1b, stress activated protein kinase beta, Stress activated protein kinase JNK3, Stress-activated protein kinase JNK3,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

53 kDa

Applications:

WB ICC/IF FC

Usage:

WB:1:500 FC:1:50-1:100 ICC:1:100-1:500

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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