Background:

The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged is a membrane protein and can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Jagged is expressed in adult and fetal tissues, and expression is upregulated in cervical squamous cell carcinoma. Familial Tetralogy of Fallot, the most common form of complex congenital heart disease, is caused by a mutation in the Jagged1 gene.

Specificity:

Jagged1 polyclonal antibody detects endogenous levels of Jagged1 protein.

Alternative names:

Jagged1, hJ1, JAG1, AGS, AHD, AWS, CD 339, CD339, CD339 antigen, Headturner, hJ1, Htu, Jag 1, Jag1, JAG1, Jagged 1, Jagged1 (Alagille syndrome), Jagged1, JAGL1, MGC104644, OTTHUMP00000030278, Protein jagged-1, Ser 1, Ser1, Serrate 1, Slalom,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

134 kDa

Applications:

WB IHC

Usage:

WB:1:1,000 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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