Background:

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

Specificity:

IP3 Receptor polyclonal antibody detects endogenous levels of IP3 Receptor protein.

Alternative names:

IP3R 1, InsP3R1, Type 1 InsP3 receptor, ITPR1, INSP3R1, 4, 5-trisphosphate receptor, 5-trisphosphate receptor type 1, DKFZp313E1334, DKFZp313N1434, inositol 1 4 5 triphosphate receptor type 1, Inositol 1 4 5 trisphosphate Receptor Type 1, Inositol 1, InsP3R1, IP3, IP3 receptor, IP3 receptor isoform 1, IP3R 1, IP3R, IP3R1, ITPR 1, Itpr1, ITPR1, SCA15, SCA16, SCA29, Type 1 inositol 1 4 5 trisphosphate receptor, Type 1 inositol 1, Type 1 InsP3 receptor,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

314 kDa

Applications:

WB IHC

Usage:

WB:1:500 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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