Background:

Alpha-internexin is a brain specific type IV intermediate filament protein. This axonal protein is found in most, if not all, neurons of the CNS. The head domain of alpha-internexin is essential for self-assembly into a filament network. Expression levels of alpha-internexin have been shown to be maximal during late embryogenesis and to decline into adulthood, suggesting that this protein plays a role in regulatory processes during the development of the brain. The alpha-internexin promoter has been shown to be activated by Brn-3a or Brn-3c transcription factor binding, while Brn-3b binding to the promoter results in alpha-internexin repression.

Specificity:

Internexin α polyclonal antibody detects endogenous levels of Internexin α protein.

Alternative names:

Alpha-Inx, NF-66, Neurofilament-66, INA, NEF5, 66 kDa neurofilament protein, AINX, Alpha Inx, Alpha-internexin, Alpha-Inx, INA, Internexin neuronal intermediate filament protein alpha, MGC12702, NEF 5, NEF5, Neurofilament 5 (66kD), Neurofilament 5, Neurofilament 66, Neurofilament 66 tax binding protein, Neurofilament-66, NF 66, NF-66, NF66, TXBP 1, TXBP1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

66 kDa

Applications:

WB ICC/IF IHC FC IP

Usage:

WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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