Integrin α4 polyclonal antibody BS90720
Specifications
| 50ul/100ul |
Background:
Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Specificity:
Integrin α4 polyclonal antibody detects endogenous levels of Integrin α4 protein.
Alternative names:
ITGA4, CD49d, 269C wild type, Antigen CD49D, alpha 4 subunit of VLA 4 receptor, CD49 antigen like family member D, CD49 antigen-like family member D, CD49d, IA4, Integrin alpha 4, Integrin alpha 4 subunit, Integrin alpha IV, Integrin alpha-4, Integrin alpha-IV, Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor), ITA4, ITGA4, MGC90518, OTTHUMP00000205320, Very late activation protein 4 receptor, alpha 4 subunit, VLA 4 subunit alpha, VLA-4 subunit alpha, VLA4,
Species reactivity:
Human
Host:
Rabbit
Ig type:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Immunogen:
recombinant protein
Purification & Purity:
ProA affinity purified
Molecular weight:
150 kDa
Applications:
WB IHC FC
Usage:
WB:1:500-1:1,000 IHC:1:50-1:200 FC:1:10-1:50
Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Precautions:
For research use only, not for use in diagnostic procedure.
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com