Background:

HSD11B1(Corticosteroid 11-beta-dehydrogenase isozyme 1) is also named as HSD11, HSD11L,11-DH and 11-beta-HSD1.It is a microsomal enzyme, which acts mainly as a NADP(H)- dependent reductase converting inactive cortisone (E) to active cortisol (F), thus regulating intracellular F access to glucocorticoid receptor. This enzyme is widely expressed not only in liver and adipose tissue, but also in adrenal, ovary and decidua.Western blot analysis in human liver, using a specific11-beta-HSD1 antibody, showed two bands at approximately 34 and 68 kDa confrming the dimeric nature of 11-beta-HSD1 in liver and In omental adipose tissue, an additional band of 50 kDa was strongly expressed.

Specificity:

HSD11B1 polyclonal antibody detects endogenous levels of HSD11B1 protein.

Alternative names:

11-DH, 11-beta-HSD1, HSD11B1, HSD11, HSD11L, SDR26C1, 11 beta HSD 1, 11 beta HSD1, 11 beta hydroxysteroid dehydrogenase 1, 11 DH, 11-beta hydroxysteroid dehydrogenase, type 1, 11-beta-HSD1, 11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11DH, Corticosteroid 11 beta dehydrogenase isozyme 1, Corticosteroid 11-beta-dehydrogenase isozyme 1, CORTRD2, DHI1, HDL, HSD 11, HSD11, HSD11B, HSD11B1, HSD11L, Hydroxysteroid (11 beta) dehydrogenase, Hydroxysteroid (11 beta) dehydrogenase 1, MGC13539, SDR26C1, short chain dehydrogenase/reductase family 26C, member 1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

32 kDa

Applications:

WB IHC

Usage:

WB:1:500-1:2,000 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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