Background:

Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.

Specificity:

hnRNP Q polyclonal antibody detects endogenous levels of hnRNP Q protein.

Alternative names:

hnRNP Q, GRY-RBP, SYNCRIP, HNRPQ, NSAP1, cytoplasmic RNA-interacting protein, dJ3J17.2, Glycine and tyrosine rich RNA binding protein, Glycine- and tyrosine-rich RNA-binding protein, GRY RBP, GRY-RBP, GRYRBP, Heterogeneous nuclear ribonucleoprotein Q, hnRNP Q, HNRPQ, HNRPQ, HNRPQ1, NS1 associated protein 1, NS1-associated protein 1, NSAP1, pp68, RP1 3J17.2, Synaptotagmin binding cytoplasmic RNA interacting protein, Synaptotagmin-binding, Syncrip,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein to C-terminal human hnRNP Q.

Purification & Purity:

ProA affinity purified

Molecular weight:

70 kDa

Applications:

WB ICC IF IHC

Usage:

WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com