Background:

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules.

Specificity:

HEC1 polyclonal antibody detects endogenous levels of HEC1 protein.

Alternative names:

HsHec1, NDC80, HEC, HEC1, KNTC2, from Entrez Gene ;, HEC, Highly expressed in cancer, Highly expressed in cancer protein, Highly expressed in cancer rich in leucine heptad repeats, HsHec1, hsNDC80, Kinetochore associated 2, Kinetochore associated protein 2, Kinetochore protein Hec1, Kinetochore protein NDC80 homolog, Kinetochore-associated protein 2, KNTC2, ndc80, NDC80 homolog kinetochore complex component, NDC80 kinetochore complex component homolog, NDC80, S. cerevisiae, homolog of, NDC80, Retinoblastoma associated protein HEC, Retinoblastoma-associated protein HEC, TID3,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human HEC1 300-500 aa.

Purification & Purity:

Protein affinity purified.

Molecular weight:

74 kDa

Applications:

WB FC

Usage:

WB:1:500 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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