Background:

Gametocyte-specific factor 1 (Gtsf1), also known as the computationally obtained undifferentiated and/or embryonic stem cell-specific 110 gene (Cue110). Gtsf1 encodes a 167-amino acid protein that is a member of the Uncharacterized Protein Family 0224. DmGTSF1 is essential for P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA)-mediated transcriptional repression and histone H3K9me3-mediated repression of transposons and their neighboring genes in the ovary. DmGTSF1 interacts with Piwi via its C-terminal tail and the two CHHC zinc-finger motifs within the DmGTSF1 protein are required for its activity. The Gtsf1 gene is essential for spermatogenesis and has been revealed to function in transposon suppression in the mouse testes. GTSF1 transcript expression has been observed to be up-regulated in certain leukemias and in lymphomas.

Specificity:

GTSF1 polyclonal antibody detects endogenous levels of GTSF1 protein.

Alternative names:

Gtsf1, 56699, Cue110, Fam112b, Family with sequence similarity 112 member B, FLJ32942, Gametocyte-specific factor 1, GTSF1, GTSF1, Protein FAM112B antibody

Species reactivity:

Zebrafish

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within zebrafish GTSF1 aa 20-170.

Purification & Purity:

Protein affinity purified.

Molecular weight:

35 kDa, predicted band size 21 kDa

Applications:

WB IF IHC

Usage:

WB:1:200 IF:1:50-1:200 IHC:1:50-1:200

Storage:

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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