Background:

The GRIM family of proteins appear to be novel types of tumor suppressors. Grim19, which stands for gene associated with retinoic-interferon-induced mortality 19 protein, is also designated cell death-regulatory protein Grim-19 or NADH dehydrogenase ubiquinone 1 alpha subcomplex subunit 13. The Grim19 protein plays two roles within the cell. As a member of the interferon-beta and retinoic acid-induced pathway of cell death, Grim19 induces apoptosis. As part of the mitochondrial complex I, Grim19 is essential for its assembly and electron transfer activity. It transfers electrons to the respiratory chain from NADH and plays a role in the interferon/all-trans-retinoic acid (IFN/RA) cell death pathway. It localizes primarily to the mitochondrion, but may translocate to the nucleus upon IFN/RA treatment. Grim19 may also be useful as a biological marker or target for drug development.

Specificity:

GRIM19 polyclonal antibody detects endogenous levels of GRIM19 protein.

Alternative names:

CI-B16.6, GRIM-19, Gene associated with retinoic and IFN-induced mortality 19 protein, NDUFA13, GRIM19, 2700054G14Rik, AU022060, B16.6, CDA016, Cell death regulatory protein, Cell death regulatory protein GRIM-19, CGI-39, CGI39 protein, CI-B16.6, Complex I-B16.6, FLJ58045, FLJ59191, Gene associated with retinoic and IFN-induced mortality 19 protein, Gene associated with retinoic and interferon-induced mortality 19 protein, Gene associated with retinoic interferon induced mortality 19 protein, GRIM-19, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, NADH ubiquinone oxidoreductase B16.6 subunit, NADH-ubiquinone oxidoreductase B16.6 subunit, NDUAD, NDUFA13, RGD1565358,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human GRIM19 aa 1-150.

Purification & Purity:

ProA affinity purified

Molecular weight:

17 kDa

Applications:

WB IHC ICC

Usage:

WB:1:500-1:1,000 IHC:1:50-1:200 ICC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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