Background:

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

Specificity:

GOT1 polyclonal antibody detects endogenous levels of GOT1 protein.

Alternative names:

cAspAT, cCAT, GOT1, CGI-141, GCT2, Germ cell tumor 2, Golgi transport 1 homolog B, Golgi transport 1B, GOLT1B, GOT1, GOT1B, hGOT1a, Putative NF-kappa-B-activating protein 470, Vesicle transport protein GOT1B, YMR292W,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein with Human GOT1 aa 1-200.

Purification & Purity:

Protein affinity purified.

Molecular weight:

46 kDa

Applications:

WB IHC FC

Usage:

WB:1:500 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com