Background:

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).

Specificity:

Gemin 1 polyclonal antibody detects endogenous levels of Gemin 1 protein.

Alternative names:

SMN1, SMN, SMNT, BCD541, Component of gems 1, Gemin 1, Gemin-1, OTTHUMP00000125198, OTTHUMP00000223567, OTTHUMP00000223568, OTTHUMP00000224066, OTTHUMP00000226924, SMA 1, SMA 2, SMA 3, SMA 4, SMA, SMA@, SMA1, SMA2, SMA3, SMA4, SMN, SMN, SMN1, SMN2, SMNT, Survival motor neuron protein, Survival of motor neuron 1, telomeric, T-BCD541,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human Gemin 1 aa 1-200.

Purification & Purity:

ProA affinity purified

Molecular weight:

32 kDa

Applications:

WB IHC IP

Usage:

WB:1:500-1:1,000 IHC:1:50-1:200 IP:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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