Background:

GAP-43 (growth associated protein 43, B-50, PP46, calmodulin-binding protein P-57, neuromodulin, neuron growth-associated protein 43, protein F1 is a crucial component for regenerative response in the nervous system. It is present at high levels in neuronal growth cones during development and axonal regeneration. GAP-43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system. The neuron-specific Elav/Hu family member, HuD, interacts with and stabilizes GAP-43 mRNA in developing neurons and leads to increased levels of GAP-43 protein. Heterozygous GAP-43 knockout mice with GAP-43 levels reduced by one-half dipslay significant memory impairments in cued conditioning or on tests of nociceptive or auditory perception.

Specificity:

GAP43 polyclonal antibody detects endogenous levels of GAP43 protein.

Alternative names:

GAP43, Axonal membrane protein GAP 43, Axonal membrane protein GAP-43, B 50, Calmodulin binding protein P 57, F1, GAP 43, GAP43, Growth Associated Protein 43, Growth-associated protein 43, Nerve Growth Related Peptide, Nerve growth related peptide GAP43, NEUM, Neural phosphoprotein B 50, Neural phosphoprotein B-50, Neuromodulin, Neuron growth associated protein 43, PP46, Protein F1, QtrA-11580, QtrA-13071,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

48 kDa

Applications:

WB ICC/IF IHC IP FC

Usage:

WB:1:2,000-1:5,000 ICC:1:100-1:500 IHC:1:100-1:500 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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