Background:

GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.

Specificity:

GABA A Receptor α5 polyclonal antibody detects endogenous levels of GABA A Receptor α5 protein.

Alternative names:

GABRA5, GAA 5, GAA5, GABA(A) receptor subunit alpha-5, GABRA 5, Gabra5, Gamma aminobutyric acid GABA A receptor alpha 5, Gamma aminobutyric acid GABA A receptor alpha 5 precursor, Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor, Gamma-aminobutyric acid receptor subunit alpha-5, GBRA5, GC138184,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

52 kDa

Applications:

WB ICC IF IHC

Usage:

ICC/IF:1:50-1:200 IHC:1:50-1:200 WB:1:500

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com