Background:

During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.

Specificity:

Fusion glycoprotein F0 polyclonal antibody detects endogenous levels of Fusion glycoprotein F0 protein.

Alternative names:

F, Fusion glycoprotein F0, Fusion glycoprotein F1, Fusion glycoprotein F2, Fusion protein (F), RSV fusion protein,

Species reactivity:

Avian avulavirus 1

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide corresponding to Avian avulavirus 1 Fusion glycoprotein F0 aa 540-554.

Purification & Purity:

Peptide affinity purified.

Molecular weight:

59 kDa

Applications:

WB ELISA

Usage:

WB:1:500-1,000 ELISA:1:5,000-1:10,000

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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