Background:

Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Specificity:

Frizzled 8 polyclonal antibody detects endogenous levels of Frizzled 8 protein.

Alternative names:

Fz-8, hFz8, FZD8, Frizzled 8 seven transmembrane spanning receptor, frizzled 8, seven transmembrane spanning receptor, Frizzled family receptor 8, frizzled homolog 8 (Drosophila), Frizzled homolog 8, Frizzled-8, FZ 8, Fz-8, FZ8, FZD 8, FZD8, FZD8, hFZ 8, hFz8, HGNC4046, Homolog of Drosophila Frizzled 8,

Species reactivity:

Human, Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

Predicted band size 73 kDa

Applications:

WB IHC

Usage:

WB:1:500-1:1,000 IHC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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