Background:

The Fox family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. FOXM1, also known as FKHL16, MPP2 or Trident, is primarily expressed in proliferating cells. The gene encoding human FOXM1 maps to chromosome 12p13. The transcription element that restricts FOXM1 expression to proliferating cells is located 300 bp upstream of the start codon. FOXM1 is most abundant in thymus, testis, small intestine and colon. Alternative splicing generates FOXM1A and FOXM1B isoforms that contain PEST regions involved in rapid protein degradation. A decrease in FOXM1 expression is associated with age-related defects in cellular proliferation. Conversely, an increase in FOXM1B expression in the livers of older transgenic mice restore hepatocyte DNA replication rates to the higher rate present in young livers. FOXM1B activates the transcription of cyclin B1, cyclin D1 and Cdc25B.

Specificity:

FOXM1 polyclonal antibody detects endogenous levels of FOXM1 protein.

Alternative names:

HFH-11, HNF-3/fork-head homolog 11, FOXM1, FKHL16, HFH11, MPP2, WIN, FKHL16, Forkhead box M1, Forkhead box protein M1, forkhead like 16, Forkhead-related protein FKHL16, FOX M1, Foxm1, FOXM1, FOXM1B, Hepatocyte nuclear factor 3 forkhead homolog 11, HFH-11, HFH11, HNF-3/fork-head homolog 11, HNF3, INS1, M phase phosphoprotein 2, M-phase phosphoprotein 2, MPHOSPH2, MPM-2 reactive phosphoprotein 2, MPP2, PIG29, TGT3, Transcription factor Trident, Trident, WIN, Winged-helix factor from INS-1 cells, Winged-helix factor from INS1 cells,

Species reactivity:

Human, Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein.

Purification & Purity:

Protein affinity purified.

Molecular weight:

84 kDa

Applications:

WB ICC FC

Usage:

WB:1:500 ICC:1:500-1:2,000 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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