Background:

Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5' untranslated region of the gene. In fragile X syndrome this tandem repeat is substantially amplified and subjected to extensive methylation and enhanced transcriptional silencing. The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. It contains several features that are characteristics of RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box). FMR1 localizes to both the nucleus and the cytoplasm and can also interact with two fragile X syndrome related factors, FXR1 and FXR2, which form heterodimers through their N-terminal coiled-coil domains. Since FMR1 contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleocytoplasmic transport of mRNAs.

Specificity:

FMRP polyclonal antibody detects endogenous levels of FMRP protein.

Alternative names:

FMRP, Protein FMR-1, FMR1, FMR 1, Fmr1, Fmr1 gene, FMR1, FMRP, Fragile X mental retardation 1, Fragile X mental retardation 1 protein, Fragile X mental retardation protein 1, Fragile X mental retardation protein, fragile X mental retardation syndrome-related protein 1, fragile X mental retardation, autosomal homolog 1, FRAXA, fxr1, MGC87458, POF, POF1, Protein FMR-1, Protein FMR1, wu:fb16f11, wu:fd18c10, zgc:66226,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

71 kDa

Applications:

WB ICC/IF IHC

Usage:

WB:1:5,000-1:10,000 ICC:1:100-1:500 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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