Background:

Cellular apoptosis susceptibility protein (CAS), also called Exportin 2, is a 971 amino acid member of the CSE1 family. CAS mediates Importin α re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm. In the nucleus, CAS binds cooperatively to Importin α and to the GTPase Ran in its GTP-bound (active) form. This complex binds to nucleoporins as it docks to the nuclear pore complex. Once in the cytoplasm, the complex dissociates and Importin α is released and CAS returns to the nuclear compartment and the process begins anew. CAS can be detected highly in proliferating cells. Three isoforms of CAS have been named due to alternative splicing. Isoform 1 is the full length, 971 amino acid protein. Isoform 2 contains an alternative sequence for amino acids 190-195 and is missing amino acids 196-971. Isoform 3 contains an alternative sequence for amino acids 943-945 and is missing amino acids 946-971.

Specificity:

Exportin-2 polyclonal antibody detects endogenous levels of Exportin-2 protein.

Alternative names:

Exp2, CSE1L, CAS, XPO2, CAS, Cellular apoptosis susceptibility protein, Chromosome segregation 1 (yeast homolog) like, Chromosome segregation 1 Like, Chromosome segregation 1 like protein, Chromosome segregation 1-like protein, Chromosome segregation gene CSE1, CSE 1, CSE 1 chromosome segregation 1 like, CSE 1 chromosome segregation 1 like protein, CSE 1L, CSE1, CSE1 chromosome segregation 1 like (yeast), CSE1 chromosome segregation 1 like, CSE1 chromosome segregation 1 like protein, CSE1L, Exp 2, Exp2, Exportin 2, Exportin-2, Exportin2, Importin alpha re exporter, Importin-alpha re-exporter, MGC117283, MGC130036, MGC130037, XPO 2, XPO2, XPO2,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

110 kDa

Applications:

WB ICC IF IHC FC

Usage:

WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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