Background:

Estrogen related receptor alpha (ERRα) is a nuclear receptor in the superfamily of ligand-regulated transcription factors and is a member of the NR3B orphan nuclear receptor subgroup (consisting of α, β and γ). ERRα plays a role in modulating the estrogen signaling pathway. In addition, the expression of ERRα has been shown to increase during fasting and cold exposure. ERRα may be important for regulating mitochondrial biogenesis and oxidative metabolism by acting directly on genes necessary for mitochondrial function. Mice lacking ERRα are unable to maintain their body temperature in the cold. ERRα may also be involved in the maintenance and formation of cartilage. This information could be useful in finding therapeutic agents for a variety of diseases affecting the joints.

Specificity:

ESRRA polyclonal antibody detects endogenous levels of ESRRA protein.

Alternative names:

ERR-alpha, ESRRA, ERR1, ESRL1, NR3B1, Err 1, ERR a, ERR alpha, ERR-alpha, Err1, ERR1 protein, ERR1, ERRa, ERRalpha, ESRL 1, ESRL1, ESRR A, Esrra, Estrogen receptor like 1, Estrogen receptor related 1, estrogen receptor related receptor alpha, Estrogen receptor-like 1, Estrogen related receptor alpha, Estrogen-related receptor alpha, Estrra, hERR1, NR3B1, Nuclear receptor subfamily 3 group B member 1, Steroid hormone receptor ERR1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

Protein affinity purified.

Molecular weight:

53 kDa

Applications:

WB FC

Usage:

WB:1:500 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com