Background:

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both the Thr and Tyr residues is required for full enzymatic activation. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.

Specificity:

ERK5 polyclonal antibody detects endogenous levels of ERK5 protein.

Alternative names:

MAP kinase 7, MAPK 7, BMK-1, ERK-5, MAPK7, Big MAP kinase 1, BMK 1, BMK 1 kinase, BMK-1, BMK1, BMK1 Kinase, EC 2.7.11.24, ERK 4, ERK 5, ERK-5, ERK4, ERK5, Extracellular signal regulated kinase 5, Extracellular signal-regulated kinase 5, MAP kinase 7, MAPK 7, MAPK7, Mitogen activated protein kinase 7, Mitogen-activated protein kinase 7, MK07, OTTHUMP00000065906, OTTHUMP00000065907, PRKM 7, PRKM7, PROTEIN KINASE, MITOGEN-ACTIVATED, 7,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

115 kDa

Applications:

WB ICC/IF IP FC

Usage:

WB:1:1,000-1:2,000 ICC:1:100-1:500 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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