Background:

The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.

Specificity:

EGR2 polyclonal antibody detects endogenous levels of EGR2 protein.

Alternative names:

EGR-2, EGR2, KROX20, AT591, CMT1D, CMT4E, DKFZp686J1957, E3 SUMO-protein ligase EGR2, Early growth response 2, Early growth response protein 2, EGR-2, egr2, EGR2, FLJ14547, KROX 20 Drosophila homolog, Krox 20 homolog Drosophila, KROX-20, Drosophila, homolog (early growth response-2), KROX20, Krox20 protein, Zinc finger protein Krox-20,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Purification & Purity:

ProA affinity purified

Molecular weight:

50 kDa

Applications:

WB FC

Usage:

WB:1:500-1:1,000 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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