Background:

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 13 belongs to the intermediate filament family and is a heterotetramer of two type I acidic and two type II basic keratins. It is generally associated with cytokeratin 4. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN), a rare autosomal dominant disorder which predominantly affects noncornified stratified squamous epithelia and is characterized by the presence of soft, white and spongy plaques in the oral mucosa.

Specificity:

Cytokeratin 13 polyclonal antibody detects endogenous levels of Cytokeratin 13 protein.

Alternative names:

CK-13, K13, KRT13, 47 kDa cytokeratin, CK-13, CK13, Cytokeratin 13, Cytokeratin-13, K13, K1C13, Ka13, Keratin 13, Keratin, keratin type I cytoskeletal 13, Keratin-13, Krt-1.13, Krt1-13, KRT13, MGC161462, MGC3781, type I cytoskeletal 13, Type I keratin Ka13, WSN2,

Species reactivity:

Human, Mouse, zebrafish

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

50 kDa

Applications:

WB ICC IHC

Usage:

WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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