Background:

Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.

Specificity:

CTDSPL polyclonal antibody detects endogenous levels of CTDSPL protein.

Alternative names:

CTDSP-like, NLI-interacting factor 1, hYA22, SCP3, Small CTD phosphatase 3, CTDSPL, C3orf8, NIF1, NIFL, SCP3, YA22, C3orf8, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like, CTD small phosphatase-like protein, CTDSL, CTDSP-like, Ctdspl, hYA22, N-like protein, NIF-like protein, NLI-interacting factor 1, Nuclear LIM interactor-interacting factor 1, Protein YA22, RB protein serine phosphatase from chromosome 3, RBSP3, SCP3, Small C-terminal domain phosphatase 3, Small CTD phosphatase 3,

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human CTDSPL aa 50-300.

Purification & Purity:

Protein affinity purified.

Molecular weight:

31kDa

Applications:

WB FC

Usage:

WB:1:500 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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