Background:

Protein transport across the nucleus is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin alpha1 and karyopherin beta1 subunits. p62 glycoprotein is a nucleoporin that is not only involved in the nuclear import of proteins, but also the export of nascent mRNA strands. NTF2 (nuclear transport factor 2) interacts with nucleoporin p62 as a homodimer composed of two monomers, and may be an obligate component of functional p62. CRM1 has been shown to be an export receptor for leucine-rich proteins that contain the nuclear export signal (NES).

Specificity:

CRM1 polyclonal antibody detects endogenous levels of CRM1 protein.

Alternative names:

Exp1, XPO1, CRM1, Chromosome region maintenance 1 protein homolog, CRM 1, CRM1 homolog, DKFZp686B1823, emb, Exp 1, Exp1, Exportin 1, Exportin-1, Exportin1, XPO 1, xpo1, XPO1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within C terminal human CRM1.

Purification & Purity:

ProA affinity purified

Molecular weight:

123 kDa

Applications:

WB ICC IF IHC FC

Usage:

WB:1:500 ICC:1:50-1:200 IHC:1:50-1:100 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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